The action potential
Outside the cell
Inside the cell
Pump
ATP
K⁺ leak
K⁺ leak
Voltage-gated
Na⁺ channel
inactivated
Voltage-gated
K⁺ channel
+
+
+
+
+
−
−
−
−
−
−
−
−
−
−
+
+
+
+
+
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
K⁺
Na⁺
Na⁺
K⁺
K⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
Na⁺
K⁺
K⁺
K⁺
K⁺
Na⁺
K⁺
Stimulus
Membrane potential (mV)
Time
−85
0
+30
Threshold
Depolarisation
Repolarisation
Brief undershoot
Na⁺
Na⁺ (sodium)
K⁺
K⁺ (potassium)
1
At rest
2
Stimulus to threshold
3
Sodium rushes in
4
Potassium flows out
5
Reset
Very few ions actually moved
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